Hotspot activating PRKD1 somatic mutations in polymorphous low-grade adenocarcinomas of the salivary glands
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چکیده
منابع مشابه
Polymorphous Low Grade Adenocarcinoma of the Parotid in a Teenager
Abstract Introduction: Polymorphous low grade adenocarcinoma (PLGA) is a rare salivary gland neoplasm with an indolent course. It occurs primarily in the minor salivary glands but can rarely occur in the major salivary glands. It usually occurs in the fifth to seventh decades of life with female preponderance. Case Report: A 16-year-old male presented with recurrent painless swelling in the r...
متن کاملimmunohistochemical pattern of pleomorphic adenoma, polymorphous low grade adenocarcinoma and adenoid cystic carcinoma in minor salivary glands.
to study the immunohistochemical pattern of cd 117, glial fibrillary acidic protein (gfap), smooth muscle actin (sma) and cd 43 in pleomorphic adenoma (pa), adenoid cystic carcinoma (adcc) and polymorphous low grade adenocarcinoma (plga) of minor salivary glands.twenty cases of pa, 20 cases of adcc and 10 cases of plga were retrieved from record files along with their paraffin blocks at armed f...
متن کاملPolymorphous low-grade adenocarcinoma.
Polymorphous low-grade adenocarcinomas are minor salivary gland neoplasms with a predilection for intraoral sites. Women are affected twice as frequently as men, and generally present in the fifth to sixth decade of life with a painless ihaoral mass. The palatal mass is, on average, about 2 cm in greatest dimension. The tumors are submucosal, identified below an intact mucosa as a well-circumsc...
متن کاملImmunohistochemical Pattern of Pleomorphic Adenoma, Polymorphous Low Grade Adenocarcinoma and Adenoid Cystic Carcinoma in Minor Salivary Glands
OBJECTIVE To study the immunohistochemical pattern of CD 117, glial fibrillary acidic protein (GFAP), smooth muscle actin (SMA) and CD 43 in pleomorphic adenoma (PA), adenoid cystic carcinoma (AdCC) and polymorphous low grade adenocarcinoma (PLGA) of minor salivary glands. MATERIALS AND METHODS Twenty cases of PA, 20 cases of AdCC and 10 cases of PLGA were retrieved from record files along wi...
متن کاملCribriform adenocarcinoma of minor salivary gland: A mimic of polymorphous low-grade adenocarcinoma
Adenocarcinoma is relatively less common on the tongue.[1] Polymorphous low‐grade adenocarcinoma (PLGA) is a malignant tumor of minor salivary glands which is slow growing and carries a low metastatic potential. Histologically, PLGA exhibits a spectrum of growth patterns such as cribriform, tubular, trabecular, fascicular and solid structures. Concentric whorls forming target‐like patterns are ...
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ژورنال
عنوان ژورنال: Nature Genetics
سال: 2014
ISSN: 1061-4036,1546-1718
DOI: 10.1038/ng.3096